Advances in Mucosal Immunology: Proceedings of the Fifth by P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P

By P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P Krajci, D Kvale, F Müller (auth.), Thomas T MacDonald PhD MRCPath, Stephen J Challacombe PhD BDS MRCPath, Paul W Bland PhD, Christopher R Stokes PhD, Richard V Heatley MD MRCP, Allan Mcl Mowat Ph

The immunology of mucosal surfaces is among the most fun and correct components of scientific veterinary and dental study because it applies easy examine to tissues in­ volved in daily defence opposed to microbes and opposed to environmental and nutrients antigens. This ebook is predicated at the contributions awarded on the overseas Con­ gress of Mucosal Immunology, held in London in July 1989 and organised by means of the Mu­ cosal Immunology Affinity team of the British Society for Immunology. The meet­ ing was once attended by way of over 500 delegates from 27 international locations, together with nearly all the best investigators within the box. The contents provide complete and up-to­ date info on such themes as antigen presentation and processing within the intestine, mucosal vaccines in guy and animals, HIV an infection within the intestine, the position of yo T cells within the intestine epithelium, fresh advances in inflammatory bowel ailment and coeliac dis­ ease, the position of cytokines within the rules of the IgA reaction, mucosal mast cells and mobile migration. The contributions mirror the fast velocity of study in mucosal immunology, and the nice strides that are happening within the knowing of the immunology, molecular biology and biochemistry of host reaction at mucosal sur­ faces.

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Speculations on the reasons for this difference in processing might include: differences in the molecular structure and antigen-binding capacity of macrophage and enterocyte class II molecules; or an entirely different role for the class II molecule in the two cell types (we have already proposed that the major role of enterocyte class II may be as a recycling antigen receptor, enhancing selective and protected transcytosis of certain antigens during absorption )(Bland, 1988). A third level of antigen processing in the gut - by the class II-bearing macrophage of the lamina propria - was not part of this study.

164, 501-516. 42. , Sugerman, H. O. (1988) 'Regulatory activity of the human CD8+ subset: a comparison of CD8+ cells from the intestinal lamina propria and blood', Eur. J. Immunol. 18, 21-27. 43. Nicklin, S. and Miller, K. (1983) 'Local and systemic immune responses to intestinally presented antigen', Int. Archs. Allergy Appl. Immun. 72, 87-90. 44. Mayer, L. and Eisenhardt, D. P. ), Inflammatory Bowel Disease: Current Status and Future Approach. Excerpta Medica, Amsterdam, pp. 9-16. 45. , Vartdal, F.

ANIMALS Male DA (RTlavl) rats, obtained either from Harlan-Olac Ltd (Bicester, Oxon), or from our own barrier-reared colony, were used when 8-10 weeks old. , Poole, Dorset), which contains no egg proteins. The litter from a Large White sow was weaned at three weeks of age onto an experimental diet containing 20% protein comprising SO% soya protein and SO% dried egg powder. Piglets were trough-fed and were used in investigations at the times stated after feeding. 2. , Poole, Dorset) was used without modification.

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